This is one of my kids' favourite experiments - blowing up a balloon without blowing! Learn how to blow up a balloon with vinegar and baking soda. Blow up a balloon with science - how cool is that :) To do the blow up the balloon experiment we will need bottles, balloons, vinegar and baking soda. Blowing a balloon with vinegar and baking soda explanation: When baking soda (a base) and vinegar (an acid) are mixed together they create a chemical reaction that results in the formation of carbon dioxide gas. ... As the carbon dioxide gas fills the balloon, the balloon inflates. The more gas that is created, the larger the balloon will inflate.